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C-Ha-ras oncogene in oral leukoplakia tissues
1Department of Stomatology, Tongji Hospital, Tongji Medical University, Wuhan.
Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
|January 1, 1996
Abstract:
The amplification and the G-T mutation at codon 12 of the C-Ha-ras oncogene in oral leukoplakia tissues were analyzed by using polymerase chain reaction (PCR) and molecular biologic technique. The results showed that these tissues had no amplification of Ha-ras oncogene. Only one case harbored G-T mutation in 11 oral leukoplakias, but this mutation was absent in 10 normal oral mucosal tissues. The possible role and significance of C-Ha-ras oncogene in oral precancerous lesions were also discussed.