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[Gonadotropins stimulate the proliferation of human epithelial ovarian cancer cell]
Objective:
To observe the effect of FSH and LH on the proliferation of human epithelial ovarian cancer cell.
Method:
Human epithelial ovarian cancer AO cells were incubated with follicle stimulating hormone (FSH) and luteinizing hormone (LH) (2U/L and 2.5U/L respectively). They were detected for proliferation by the use of the immunohistochemical technique and morphology.
Results:
The positive rate of proliferating cell nuclear antigen expressed in the cancer cell was increased significantly (p < 0.05) indicating its proliferation stimulating effect by FSH. The mitosis of cancer cells was increased by FSH and by LH (35%, 16% respectively).
Conclusions:
It is suggested that FSH and LH can stimulate the proliferation of epithelial ovarian cancer cell, and they may play an important in the development of epithelial ovarian cancer.