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[An experimental study on the treatment of fetal rabbits with intrauterine growth retardation]
1Third Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou.
Objective:
To investigate the effect of histocyte activators and vasodilators on the amino acids concentration in fetal rabbits with intrauterine growth retardation (IUGR).
Methods:
The rabbits with IUGR were caused by passive smoking and treated with histocyte activators (adenosine triphosphatase, coenzyme A, cytochrome C, and vasodilators (injectio salviac molfiorrhizae composita, anisodamine). The effects of different remedies on the fetal plasma amino acids' concentration and the fetal development (i.e. birth weight, the weights of fetal liver and fetal brain) were studied.
Results:
Both histocyte activators and vasodilators had favorable effects on the improvement of fetal development and the increase of fetal plasma amino acids' concentration. But the action of histocyte activators was stronger than vasodilators.
Conclusions:
The results suggested that vasodilators could improve the uterine-placental flow, and histocyte activators could enhance placental transfer of amino acids. But histocyte activators seem to be better than vasodilators.