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[Detection of placental alkaline phosphatase in ovarian cancer]
Objective:
To establish a method for diagnosis of malignant tumors by determination of the placental alkaline phosphatase (PLAP) in serum.
Methods:
A solid phase enzyme immunoassay was adopated by an antibody against PLAP. PLAP in serum of 81 patients with malignant tumor and 86 healthy people as control were determined.
Results:
In the control group, the PLAP activity showed deviative distribution, the 95th percentile values of PLAP in control group was 3.8U/L. If this value served as normal cut-off line, 18 cases among 81 patients with malignant tumors were positive. The positive rate was 22.2%, but the positive rates in ovarian cancer was 61.9%.
Conclusions:
The increasing of serum PLAP may be helpful for the diagnosis of malignant tumors especially ovarian cancer.