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Lycaconitine revisited: partial synthesis and neuronal nicotinic acetylcholine receptor affinities
J M Jacyno1, J S Harwood, N H Lin
1College of Pharmacy, Ohio Northern University, Ada 45810, USA.
Journal of Natural Products
|July 1, 1996
Abstract:
The norditerpenoid alkaloid lycaconitine (2) was synthesized from lycoctonine (3) and its affinity determined for two neuronal nicotinic acetylcholine receptor subtypes. The structure of 2 was confirmed by a combination of spectroscopic methods.