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Submucosal glands after maxillary sinus surgery. An experimental study in rabbits
P J Melgarejo-Moreno1, I Ribera-Cortada, D Hellin-Meseguer
1Department of Otolaryngology, School of Medicine, Hospital Arnau de Vilanova, Lleida, Spain.
The Journal of Laryngology and Otology
|July 1, 1996
Summary
Surgical removal of rabbit maxillary sinus mucosa reduced serous glands and caused inflammation. Regenerated mucosa showed secretory cell changes, impacting sinus gland function.
Area of Science:
- Otorhinolaryngology
- Oral and Maxillofacial Surgery
- Histopathology
Background:
- The maxillary sinus submucosal glands' role in sinus health is not fully understood.
- Surgical interventions may impact these glands and subsequent sinus physiology.
Purpose of the Study:
- To investigate the effects of maxillary sinus mucosa removal on submucosal glands in New Zealand White rabbits.
- To evaluate the histopathological and ultrastructural changes in regenerated sinus mucosa.
Main Methods:
- Unilateral partial or complete maxillary sinus mucosa removal in 30 rabbits.
- Histopathological examination, bacteriological cultures, and light and electron microscopy of sinus specimens after three months.
- Comparison between operated and control sinuses.
Main Results:
- Complete surgical removal led to a significant decrease in serous glands and notable inflammation.
- Histopathology confirmed reduced serous gland counts in operated sinuses.
- Electron microscopy identified alterations in the secretory cells of serous glands within the regenerated mucosa.
Conclusions:
- Partial or complete removal of maxillary sinus mucosa negatively affects submucosal serous glands.
- Surgical regeneration of sinus mucosa involves ultrastructural changes in secretory cells, potentially impairing gland function.
- Further research is needed to understand the long-term implications for sinus health.