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Sympathetic nerve activities in pulsatile and nonpulsatile systemic circulation in anesthetized goats
1Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
The American Journal of Physiology
|July 1, 1996
Summary
Systemic circulation mode impacts sympathetic nerve activity. Converting to nonpulsatile flow increased renal nerve activity and altered its rhythmic patterns, revealing a fundamental rhythm from the vasomotor center.
Area of Science:
- Physiology
- Cardiovascular System
- Neuroscience
Background:
- Sympathetic nerve activity is crucial for regulating cardiovascular function.
- Systemic circulation can be pulsatile or nonpulsatile, potentially influencing nerve activity.
- Understanding these effects is vital for comprehending cardiovascular control mechanisms.
Purpose of the Study:
- To investigate the impact of pulsatile versus nonpulsatile systemic circulation on sympathetic nerve activity.
- To analyze changes in renal nerve activity (RNA) patterns under different circulation modes.
- To differentiate between cardiac-related rhythms and fundamental rhythms in RNA.
Main Methods:
- Utilized a left heart bypass technique in anesthetized goats.
- Converted systemic circulation between pulsatile and nonpulsatile modes.
- Analyzed the periodicity and quantity of renal nerve activity (RNA).
Main Results:
- Depulsation of systemic circulation significantly increased mean renal nerve activity (RNA).
- Periodic, pulse-related RNA discharges became obscure in nonpulsatile mode.
- An 8-12 cycle/s rhythm in RNA became dominant in nonpulsatile circulation.
Conclusions:
- Systemic depulsation leads to increased sympathetic nerve activity.
- Cardiac-related rhythms in RNA are likely mediated by arterial baroreceptors.
- The 8-12 cycle/s rhythm in RNA originates from the vasomotor center, independent of circulation type.