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Embryological considerations on a multiple vascular anomaly in a child
Insights
Internal carotid artery coiling and kinking can cause strokes, particularly in adults. This case study highlights these arterial abnormalities in a seven-month-old infant, suggesting developmental origins.
Area of Science:
- Vascular Surgery
- Pediatric Neurology
- Developmental Biology
Background:
- Internal carotid artery (ICA) coiling and kinking are implicated in cerebral ischemia, primarily in adults.
- Congenital vascular anomalies can lead to significant neurological deficits in infants.
- Understanding the developmental origins of these arterial malformations is crucial for pediatric care.
Abstract:
Coiling and kinking of the internal carotid artery are considered of remarkable importance in the pathogenesis of cerebral ischaemic episodes, especially in adults. The authors describe the case of a seven months old infant who underwent aortic and bilateral cerebral angiography because of severe neurological symptomatology. Besides serious malformations of the aorta and major vessels, both coiling of the left internal carotid artery and kinking of the right internal carotid artery were found. The arterious anomalies of the aortic branches are probably due to the deranged development of the two subclavian arteries and, in particular, of the right one. Owing to the patient's age, the carotid alterations are also consequent to an abnormal development of the arterious district deriving from the primitive aortic archs, especially the third arch.