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Related Experiment Videos

HLA antigens and atopic dermatitis

J Goudemand, C Defrenne, F Desmons

    Monographs in Allergy
    |January 1, 1977
    PubMed
    Summary

    This study found a higher frequency of HLA-BW35 antigen in children with atopy and their parents, suggesting a genetic link. While atopy is hereditary, the specific gene linkage remains under investigation.

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    Area of Science:

    • Immunogenetics
    • Allergology
    • Human Leukocyte Antigen (HLA) system

    Background:

    • Atopy, a predisposition to allergic diseases, has a known hereditary component.
    • The Human Leukocyte Antigen (HLA) system plays a crucial role in immune responses and is associated with various diseases.

    Purpose of the Study:

    • To investigate the frequency of specific HLA antigens in children with atopy and their families.
    • To explore potential genetic associations between HLA antigens and the hereditary nature of atopy.

    Main Methods:

    • Determining HLA antigen frequencies in 27 unrelated children with atopy and 44 of their parents.
    • Comparing these frequencies to a control group of 326 healthy individuals.
    • Analyzing HLA segregation patterns in 23 families with affected children and healthy siblings.

    Main Results:

    • A statistically significant increase in HLA-BW35 antigen frequency was observed in patients (37%) and their parents (34%) compared to controls (11.6%).
    • No disturbance in HLA segregation was detected within the studied families, indicating normal inheritance patterns.

    Conclusions:

    • The findings support the hereditary nature of atopy.
    • The increased prevalence of HLA-BW35 suggests a potential genetic linkage, possibly involving a HLA-B gene and an immune response (Ir) gene, influencing allergic responses.

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