HLA antigens in grass pollinosis

48 patients with grass pollinosis and strongly positive skin tests to crude timothy pollen extract, as well as the relatives of 11 of the, were typed for 26 HLA antigens of the A and B loci. No significant alteration in the frequencies of any particular antigen was observed, except for an increase of HLA-A1 and B8 in patients with multiple manifestations of reaginic disease. In the 11 families investigated, susceptibility to grass pollinosis and IgE levels did not appear to be linked to HLA haplotypes. Preliminary studies with anti-lymphocyte B sera did not reveal any significant alteration in the frequency of positive reactions, using enriched population of B lymphocytes from 16 patients.