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Effects of adrenodemedullation and adrenalectomy on the 5-HT2 receptor agonists DOI-and mCPP-induced hypophagia in
J Yamada1, Y Sugimoto, T Yoshikawa
1Department of Pharmacology, Kobe Pharmaceutical University, Japan.
Abstract:
Effects of adrenodemedullation and adrenalectomy on the serotonin2 (5-HT2) receptor agonists-induced hypophagia were investigated. Hypophagia induced by both the 5-HT2A/2C, receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and the 5-HT2C-receptor agonist 1-(3-chlorophenyl)piperazine (mCPP) were not affected by adrenodemedullation. In adrenalectomized rats. DOI did not induce hypophagia, while mCPP elicited apparent effects. These results suggest that neither DOI- nor mCPP-induced hypophagia was not associated with adrenaline release from the adrenal medulla. Moreover, our results suggest that DOI-induced hypophagia is involved in corticosterone-sensitive feeding, although other mechanisms which are not related to corticosterone are involved in mCPP-induced anorexia.