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CGP 36,742, an orally active GABAB receptor antagonist, facilitates memory in a social recognition test in rats
C Mondadori1, H J Moebius, M Zingg
1Pharmaceutical Research Department, CIBA-GEIGY Ltd., Basel, Switzerland. cesaremondadori@mmd.com
Behavioural Brain Research
|May 1, 1996
Abstract:
CGP 36,742, an orally active GABAB receptor antagonist, improves the retention performance of rats in a social recognition test. This effect is detectable over a very wide range of doses (0.03 to 300 mg/kg, p.o.). Considering its binding (32 mumol affinity for the GABAB site) the surprisingly potent activity of CGP 36,742 makes it appear quite possible that the effect is mediated by an as yet unknown receptor subtype.