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[Hormone replacement treatment and skin aging]

L Vaillant1, A Callens

  • 1Service de Dermatologie, CHU Tours, France.

Therapie
|January 1, 1996
PubMed
Summary

Hormone replacement therapy (HRT) can treat skin ageing symptoms in postmenopausal women by improving skin thickness, hydration, and collagen. This therapy addresses oestrogen deficiency, alleviating dryness and roughness associated with hormonal ageing.

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Area of Science:

  • Dermatology
  • Endocrinology
  • Gerontology

Context:

  • Skin ageing results from intrinsic, photoageing, and hormonal factors.
  • Oestrogen deficiency in postmenopausal women significantly impacts skin health.
  • The pilosebaceous unit is a target for sexual steroids, influencing skin conditions.

Purpose:

  • To investigate the potential of hormone replacement therapy (HRT) in treating symptoms of skin ageing.
  • To evaluate the effects of HRT on skin thickness, hydration, and collagen content.
  • To determine if HRT can alleviate dryness, roughness, and atrophy associated with hormonal ageing.

Summary:

  • HRT demonstrated an increase in skin thickness (10-20%) in postmenopausal women, particularly in oestrogen-treated and non-sun-exposed areas.
  • Oestrogen therapy was shown to increase fibroblast activity, dermal water, hyaluronic acid, and collagen content.
  • HRT alleviated hyposeborrhoea and improved skin complaints like roughness and dehydration, while also limiting facial hair masculinization.

Impact:

  • HRT offers a viable treatment for oestrogen-deficiency-related skin ageing.
  • The study provides evidence for HRT's role in improving skin structure and mitigating age-related changes.
  • Non-invasive measurements confirmed the positive effects of HRT on skin physical parameters.

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