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[Contractile effect of erythromycin on the gallbladder]
Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|December 1, 1995
Summary
Erythromycin causes gallbladder contraction in hamsters and humans. This antibiotic effectively treats gallbladder hypomotility, even in patients with gallstones.
Area of Science:
- Gastroenterology
- Pharmacology
Context:
- The contractile effects of erythromycin on gallbladder function remain incompletely understood.
- Investigated the impact of erythromycin on gallbladder motility in a golden hamster gallstone model and human subjects via ultrasonography.
Purpose:
- To elucidate the concentration-dependent contractile effects of erythromycin on gallbladder motility.
- To assess the efficacy of erythromycin in modulating gallbladder hypomotility in both healthy and gallstone-affected individuals.
Summary:
- Erythromycin demonstrated a concentration-dependent contractile effect on the gallbladder in both normal and gallstone-diet hamsters, with no significant differences in maximal effect or EC50.
- Clinical studies in human volunteers and patients with cholecystolithiasis showed that erythromycin significantly reduced fasting and residual gallbladder volumes while increasing ejection fraction and emptying rate.
- Erythromycin effectively modulated gallbladder hypomotility in gallstone patients.
Impact:
- Erythromycin shows therapeutic potential for managing gallbladder hypomotility disorders.
- Findings suggest erythromycin's utility in improving gallbladder emptying function, particularly in patients with gallstones.