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Further studies on the lobar heterogeneity in response to coumarin-mediated hepatotoxicity
1Department of Human Morphology, University of Nottingham Medical School, UK.
International Journal of Experimental Pathology
|April 1, 1996
Abstract:
A randomized sampling protocol coupled with quantitative morphometry has been used to evaluate the inter-lobe variation in centrilobular hepatic necrosis in the mouse, and periportal hepatic necrosis in the beta-naphthoflavone-induced rat, both in response to treatment with coumarin. The results of these studies indicate a random inter-lobe variation in xenobiotic-mediated hepatotoxicity.