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Related Experiment Videos

How viral oncogenes make the cell cycle

P Jansen-Dürr1

  • 1Deutsches Krebsforschungszentrum, Forschungs-schwerpunkt Angewandte Tumorvirologie, Heidelberg, Germany. p.jansen-duerr@dkfz-beidelberg.de

Trends in Genetics : TIG
|July 1, 1996
PubMed
Summary
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Oncogenic viruses promote cell growth by overriding normal cell cycle controls. Viral oncoproteins disrupt signaling pathways, leading to uncontrolled cell proliferation and transformation.

Area of Science:

  • Molecular Biology
  • Virology
  • Cell Biology

Background:

  • Oncogenic viruses possess viral oncogenes that confer additional growth stimuli to host cells.
  • These oncogenes can overcome crucial growth-suppressive signals governing cell-cycle progression in normal cells.

Purpose of the Study:

  • To elucidate how viral oncogenes override cellular growth controls.
  • To understand the mechanisms by which viral oncoproteins interfere with cell-cycle regulation.

Main Methods:

  • Analysis of viral oncogene function in host cells.
  • Investigation of interactions between viral oncoproteins and cellular signaling pathways.
  • Examination of gene expression changes related to cell-cycle progression.

Main Results:

Related Experiment Videos

  • Viral oncogenes override host cell growth suppressors, enhancing proliferative capacity.
  • Viral oncoproteins disrupt receptor-mediated signal transduction and nuclear regulatory proteins.
  • Many viral oncogenes upregulate cellular genes, including G1 cyclins, essential for cell-cycle progression.

Conclusions:

  • Oncogenic viruses transform cells by deregulating cell-cycle control.
  • Different oncogenic viruses utilize distinct pathways to achieve cell transformation.