Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in oxygen cost of contractility during hypocapnic alkalosis in canine hearts

K Onishi1, K Sekioka, R Ishisu

  • 1First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.

The American Journal of Physiology
|June 1, 1996
PubMed
Summary

Alkalosis enhances cardiac contractility and efficiency by reducing the oxygen cost of muscle contraction, likely through calcium sensitization. This improves the heart

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentiation-inducing activity of retinoic acid isomers and their oxidized analogs on human promyelocytic leukemia HL-60 cells.

Biochemical and biophysical research communications·1992
Same author

Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.

Journal of medicinal chemistry·1992
Same author

Substance P induces intracellular calcium increase and translocation of protein kinase C in epidermis.

The British journal of dermatology·1992
Same author

Interleukin-2 production by primary adult T cell leukemia tumor cells is macrophage dependent.

American journal of hematology·1992
Same author

Deletion of mitochondrial DNA in the endomyocardial biopsy sample from a patient with Kearns-Sayre syndrome.

European heart journal·1992
Same author

Entrainment to external Ca2+ oscillation in ionophore-treated Physarum plasmodium.

Cell structure and function·1992

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Mechanoenergetics
  • Biochemistry

Background:

  • Calcium (Ca2+) sensitization of cardiac contractile machinery can theoretically improve heart efficiency.
  • Understanding the interplay between alkalosis, Ca2+ sensitization, and cardiac mechanoenergetics is crucial for cardiovascular research.

Purpose of the Study:

  • To investigate the effects of alkalosis combined with Ca2+ sensitization on cardiac mechanoenergetics.
  • To determine how alkalosis influences myocardial oxygen consumption (VO2) and contractility (Emax).

Main Methods:

  • Studied excised, cross-circulated canine hearts (n=10) under stable alkalosis (pH 7.66) without hypoxia.
  • Analyzed relationships between left ventricular pressure-volume area (PVA), VO2, and Emax.
  • Compared the ratio of unloaded VO2 to Emax under alkalosis versus Ca2+ sensitization.

Related Experiment Videos

Main Results:

  • Alkalosis increased Emax without altering the slope of the VO2-PVA relation (contractile efficiency).
  • The ratio of unloaded VO2 to Emax was significantly lower in alkalosis compared to Ca2+ sensitization.
  • Alkalosis decreased the energy cost of excitation-contraction coupling, as basal metabolism was unaffected.

Conclusions:

  • Alkalosis decreases the oxygen cost of cardiac contractility, likely mediated by Ca2+ sensitization.
  • This finding suggests a potential therapeutic benefit of managing acid-base balance in cardiac conditions.
  • The study demonstrates a more efficient use of oxygen for generating contractile force under alkalotic conditions.