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Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
Ten year experience with infrainguinal revascularization for limb salvage
T W Klamer1, S M George, G E Lambert
1Department of Surgery, University of Louisville, KY.
Infrainguinal revascularization offers a high success rate for limb salvage in patients with severe ischemia. Long-term surveillance and reintervention are crucial for maintaining graft patency and preventing amputation.
Area of Science:
- Vascular Surgery
- Peripheral Artery Disease
- Limb Salvage Surgery
Background:
- Severe, symptomatic infrainguinal ischemia presents a critical challenge, with revascularization being the sole alternative to amputation.
- Assessing the long-term efficacy of revascularization procedures is vital for patient outcomes.
Purpose of the Study:
- To evaluate the success of infrainguinal revascularization, specifically focusing on limb salvage rates.
- To analyze a personal 10-year operative experience with these procedures.
Main Methods:
- Conducted a retrospective analysis of 312 primary infrainguinal bypass procedures on 271 patients (1983-1992).
- Included repeat revascularization for failing or failed grafts, contingent on limb viability and outflow vessel availability.
- Utilized preoperative and intraoperative angiography to assess graft status.
Main Results:
- Achieved a 5-year patient survival rate of 57% and a cumulative 72-month limb salvage rate of 72%.
- Autologous conduits demonstrated superior primary and secondary graft patency (57%/67% at 60 months) compared to nonautologous conduits (20%/21%).
- 19% of extremities required reoperations for graft failure, with 44 amputations resulting from unsuccessful revisions.
Conclusions:
- Infrainguinal revascularization is a viable treatment option with low mortality and high success rates for limb salvage.
- Emphasizes the necessity of long-term postoperative surveillance and reintervention to maintain graft patency and limb salvage.
- Highlights the superior long-term patency of autologous conduits in infrainguinal bypass surgery.
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