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Functional GABAergic synaptic connection in neonatal mouse barrel cortex

A Agmon1, G Hollrigel, D K O'Dowd

  • 1Department of Anatomy, University of California, Irvine 92717, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 1, 1996
PubMed
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Functional intracortical inhibition via GABA-A receptors is present in neonatal mice. This inhibitory network, crucial for neocortical development, shows distinct properties compared to mature circuits.

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Cortical Development

Background:

  • Intracortical inhibition is vital for mature neocortical function.
  • This inhibition is paradoxically reported as rare or absent in neonatal animals.

Purpose of the Study:

  • To re-examine the presence and nature of intracortical inhibition in the neonatal neocortex.
  • To investigate the functional properties of early-onset synaptic connections in the developing brain.

Main Methods:

  • Whole-cell recordings of postsynaptic currents (PSCs) in barrel cortex neurons of neonatal mouse brain slices.
  • Elicitation of monosynaptic excitatory and polysynaptic inhibitory responses using thalamocortical and intracortical stimulation.
  • Pharmacological manipulation using NMDA receptor (NMDAR) and GABA-A receptor (GABAAR) antagonists.

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Main Results:

  • Monosynaptic excitatory thalamocortical responses were observed as early as postnatal day 0 (P0).
  • A prolonged synaptic barrage, indicative of network activity, followed excitatory responses at low frequencies.
  • GABA-A receptor-mediated, chloride-dependent inhibitory PSCs were identified, differing in reversal potential and latency from mature responses.

Conclusions:

  • A functional network of intracortical GABA-A receptor-mediated synaptic connections exists from the earliest postnatal ages.
  • Early inhibitory responses exhibit unique characteristics compared to those in the mature neocortex.
  • These findings challenge the notion of absent intracortical inhibition in the neonatal brain.