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Genomic and cDNA structures of the gene encoding the chicken ZF5 DNA binding protein
1Department of Chemistry and Molecular Biology Institute, San Diego State University, CA 92182-1030, USA.
Abstract:
Genomic and cDNA clones encoding the chicken ZF5 transcription factor were isolated and sequenced. Conceptual translation of the cDNAs indicates that chicken ZF5 has five zinc fingers at its C-terminal end and a POZ/BTB protein-interaction domain at its N-terminal end. These two functional domains are more than 99% identical in amino acid sequence between the chicken and mouse proteins, whereas the region separating the POZ/BTB and DNA binding domains is only 74% identical. The entire 458 amino acid open reading frame is contained within a single exon, except for the initiator methionine codon which alone is supplied from an upstream exon by mRNA splicing.
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