Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypoxic pulmonary vasoconstriction]

I L Theissen1, A Meissner

  • 1Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin der Westfälischen Wilhelms-Universität Münster.

Der Anaesthesist
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of enhanced infection control and antimicrobial stewardship on infections by Clostridioides difficile, vancomycin-resistant enterococci, and third-generation cephalosporin-resistant Enterobacterales: a stepped-wedge cluster intervention study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2025
Same author

The experience of transfeminine adolescents and their parents regarding fertility preservation via testicular sperm extraction (TESE): a qualitative study.

Human reproduction (Oxford, England)·2024
Same author

Impact of respiratory infectious epidemics on STEMI incidence and care.

Scientific reports·2021
Same author

Histological study on the influence of puberty suppression and hormonal treatment on developing germ cells in transgender women.

Human reproduction (Oxford, England)·2021
Same author

Bi-allelic variants in DNA mismatch repair proteins MutS Homolog MSH4 and MSH5 cause infertility in both sexes.

Human reproduction (Oxford, England)·2021
Same author

Outbreak of Pseudomonas aeruginosa infections after CT-guided spinal injections.

The Journal of hospital infection·2021
Same journal

[Promoting young academics in anesthesiology: factors for an attractive internship].

Der Anaesthesist·2022
Same journal

[Respiratory support in COVID-19: all in due time!]

Der Anaesthesist·2022
Same journal

[Noninvasive respiratory support and invasive ventilation in COVID‑19 : Where do we stand today?]

Der Anaesthesist·2022
Same journal

[Management of acutely decompensated liver cirrhosis in emergency and critical care medicine].

Der Anaesthesist·2022
Same journal

[Anesthesia in patients with acute porphyria].

Der Anaesthesist·2022
Same journal

[Quality and safe anesthesia for all children : That is their right!]

Der Anaesthesist·2022
See all related articles

Hypoxic pulmonary vasoconstriction (HPV) redirects blood flow from poorly ventilated lung areas to better ones, improving oxygen levels. Its effectiveness depends on the extent of lung hypoxia, with optimal benefits seen when 30-70% of the lung is affected.

Area of Science:

  • Pulmonary physiology
  • Cardiovascular research
  • Respiratory medicine

Background:

  • Hypoxic pulmonary vasoconstriction (HPV) is a unique vascular feedback mechanism in the lung.
  • It redistributes blood flow from poorly ventilated to better-ventilated lung regions, reducing physiological shunt.
  • HPV is a local mechanism responding to alveolar hypoxia, crucial for ventilation-perfusion (V/Q) matching.

Purpose of the Study:

  • To elucidate the functional significance and limitations of HPV in V/Q matching.
  • To identify the optimal conditions for HPV efficacy and its detrimental effects under certain circumstances.
  • To pinpoint the anatomical location and cellular basis of the HPV response.

Main Methods:

  • Review of existing literature on HPV.

Related Experiment Videos

  • Analysis of the relationship between the extent of hypoxic lung area and its effect on PaO2.
  • Histological examination of lung sections to identify the site of constriction.
  • In vitro studies on pulmonary vascular smooth muscle cells.

    • Main Results:

    • HPV efficacy is maximal when 30-70% of the lung is hypoxic; minimal effect with small hypoxic areas.
    • Widespread hypoxia renders HPV detrimental, increasing pulmonary arterial pressure and potentially reducing cardiac output.
    • HPV response is blunted by anesthetics, vasodilators, endotoxin, low PaO2, and acid-base changes (acidosis/alkalosis inhibit it).
    • Factors like ventilation mode or chest status do not influence HPV.
    • Constriction occurs in small pulmonary arteries (<500 microns) involving smooth muscle cells responding to local oxygen tension.

    Conclusions:

    • HPV is a critical V/Q matching mechanism, but its effectiveness is contingent on the proportion of hypoxic lung tissue.
    • Understanding the limits of HPV is essential to avoid adverse effects like increased pulmonary hypertension.
    • The precise intracellular biochemical pathway mediating HPV remains to be elucidated.