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[Drug-induced pleurisy]

A Benard1, H Guenanen, I Tillie-Leblond

  • 1Service de Pneumologie et immuno-allergologie, Hôpital A. Calmette, Lille.

Revue Des Maladies Respiratoires
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

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Drug-induced pleurisy, a diagnosis of exclusion, presents non-specifically with chronic pleural effusions or thickening. Associated systemic signs and drug cessation can lead to regression, though pleural thickening may persist.

Area of Science:

  • Pulmonology
  • Pathology
  • Pharmacology

Context:

  • Drug-induced pleurisy is challenging to diagnose due to non-specific clinical and pathological features.
  • Pleural effusions are typically chronic, often bilateral, and can manifest as effusion or thickening.

Purpose:

  • To describe the characteristics, diagnostic challenges, and clinical course of drug-induced pleurisy.
  • To highlight associated systemic signs and anatomical-pathological findings.

Summary:

  • Drug-induced pleurisy presents with chronic, often bilateral pleural effusions or thickening, posing diagnostic challenges due to non-specific features.
  • Associated findings may include pulmonary, cutaneous, ocular, hepatic, peritoneal, or pericardial signs, alongside laboratory abnormalities like hypereosinophilia or antinuclear antibodies.

Related Experiment Videos

  • Histopathology reveals dense, diffuse fibrosis with minimal inflammation. Causative agents include ergotamine derivatives, bromocriptine, and dantrolene.

    • Impact:

    • Understanding these features aids in the diagnosis and management of drug-induced pleurisy.
    • Identifying causative agents is crucial for potential regression upon medication cessation.
    • Recognizing associated systemic manifestations improves patient care and diagnostic accuracy.