[Indocyanine green angiography in posterior uveitis]

Area of Science:

• Ophthalmology
• Medical Imaging
• Inflammatory Diseases

Background:

• Indocyanine-green (ICG) angiography provides insights into choroidal status in posterior inflammatory conditions.
• It holds potential as a diagnostic procedure for choroid-predominant inflammatory diseases.
• This study aimed to analyze ICG findings and correlate them with fluorescein angiography and clinical data in posterior uveitis.

Purpose of the Study:

• To evaluate the utility of ICG angiography in posterior uveitis.
• To correlate ICG findings with fluorescein angiography and clinical presentations.
• To assess ICG's role in analyzing choroidal involvement and disease progression.

Main Methods:

• ICG angiography was performed routinely in patients with posterior uveitis involving the choroid.
• The study included cases of sarcoidosis, birdshot chorioretinopathy, MEWDS, Vogt-Koyanagi-Harada disease, and multifocal choroiditis.
• ICG findings were analyzed and compared with clinical and fluorescein angiographic data.

Main Results:

• Hypofluorescent lesions, indicative of active inflammation or choroidal atrophy, were observed in all analyzed entities.
• ICG angiography identified inflammatory choroidal lesions not apparent clinically or via fluorescein angiography, except in multifocal choroiditis.
• Late-phase ICG hyperfluorescence suggested recent or acute inflammatory involvement.

Conclusions:

• ICG angiography proved beneficial in evaluating choroidal involvement and disease progression in four posterior inflammatory disorders.
• The technique is likely to be a valuable addition to the diagnostic work-up for most posterior uveitis cases affecting the choroid.