Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The lung in HIV infection: can pulmonary function testing help?

D M Mitchell1, J R Clarke

  • 1Dept of Respiratory Medicine, St Mary's Hospital Medical School, London, UK.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Further investigation of lead exposure as a potential threatening process for a scavenging marsupial species.

Australian veterinary journal·2023
Same author

Correction: Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice.

Molecular psychiatry·2020
Same author

Quantification of Ochratoxin A in Swine Kidneys by Enzyme-linked Immunosorbent Assay Using a Simplified Sample Preparation Procedure.

Journal of food protection·2019
Same author

High blood lead concentrations in captive Tasmanian devils (Sarcophilus harrisii): a threat to the conservation of the species?

Australian veterinary journal·2018
Same author

A real-time Global Warming Index.

Scientific reports·2017
Same author

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

Annals of oncology : official journal of the European Society for Medical Oncology·2017

Simple lung function tests, especially the transfer factor of the lung for carbon monoxide (TL,CO), can detect respiratory disease in HIV-infected individuals. While sensitive for pneumonitis, reduced TL,CO is not specific enough for diagnosis.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Immunology

Background:

  • Respiratory symptoms are common in individuals with human immunodeficiency virus (HIV).
  • Simple lung function tests, including transfer factor of the lung for carbon monoxide (TL,CO), are used to assess these symptoms.
  • Reduced TL,CO has been observed in patients with acquired immune deficiency syndrome (AIDS) and respiratory conditions.

Purpose of the Study:

  • To evaluate the utility of simple lung function tests in diagnosing respiratory disease in HIV-infected individuals.
  • To assess the significance of reduced TL,CO in HIV-associated pulmonary conditions.

Main Methods:

  • Analysis of lung function test data, particularly TL,CO, in HIV-infected patients with various respiratory conditions.
  • Comparison of TL,CO values across different HIV disease categories and specific pulmonary infections/neoplasms.

Related Experiment Videos

  • Evaluation of the impact of pneumocystis pneumonia recovery and Zidovudine therapy on TL,CO.

    • Main Results:

    • Reduced TL,CO was observed across all categories of HIV disease, most markedly in pneumocystis pneumonia.
    • Pulmonary bacterial infection, tuberculosis, and Kaposi's sarcoma also led to decreased TL,CO.
    • TL,CO improved after pneumocystis pneumonia recovery but rarely normalized; Zidovudine therapy did not affect lung function, while smoking worsened it.

    Conclusions:

    • A reduced TL,CO is a sensitive indicator of pneumonitis in HIV-infected individuals but lacks specificity for definitive diagnosis.
    • Simple lung function tests, particularly TL,CO, serve as valuable screening tools for underlying organic respiratory disease in HIV-seropositive patients.
    • Normal TL,CO values make pneumonitis unlikely in HIV-infected patients with respiratory symptoms.