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Synthesis and antimicrobial activity of some new piperidinyl benzimidazoles
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
Farmaco (Societa Chimica Italiana : 1989)
|June 1, 1996
Abstract:
A series of 2-(4-methylpiperidin-1-yl)-1,5(6)-disubstituted-1H-benzimidazoles (1-18) were prepared through the reaction of 2-chloro (or 2-chloromethyl)-1H-benzimidazole derivatives with 4-methylpiperidine. For the preparation of the individual isomers, compounds 7, 9 and 18 were synthesized by a multistep procedure. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compound 3 and 4 exhibited the best antifungal activity.