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Some 3-hydrazono-2-indolinones and N-Mannich bases as potential anticonvulsants
A Gürsoy1, N Karali, S Büyüktimkin
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Farmaco (Societa Chimica Italiana : 1989)
|June 1, 1996
Abstract:
In this study a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation of isatin with aryloxy/arythioxyacetylhydrazines were treated with morpholine and formaldehyde to yield 1-morpholinomethyl-3-aryloxy/arylthioxyacetylhydrazono-2- indolinones. Structures of all the compounds were assigned on the basis of spectral data (UV, IR, 1H-NMR, EIMS) and elemental analyses. Anticonvulsant evaluation of the compounds revealed varying degrees of activity against pentylenentetrazole induced seizures.