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Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. I. Synthesis and in vitro antimicrobial evaluation
F Bruni1, S Selleri, A Costanzo
1Dipartimento di Scienze Farmaceutiche, Università degli Studi di Firenze, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|June 1, 1996
Abstract:
A series of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones (9-36) was prepared by a simple synthetic procedure based on the reaction of ethyl 7-dimethylaminovinyl pyrazolo[1,5-a]pyrimidin-6-carboxylates (1-8) and reagents (a-n) containing a primary amino group. When this set of compounds was subjected to "in vitro" antimicrobial screening, it showed no significant activity.