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Type 2 autoimmune hepatitis and hepatitis C viraemia
O Leri1, S Paparo Barbaro, M T Sinopoli
1Department of Infectious and Tropical Diseases, University La Sapienza, Rome, Italy.
Rivista Europea Per Le Scienze Mediche E Farmacologiche = European Review for Medical and Pharmacological Sciences = Revue Europeenne Pour Les Sciences Medicales Et Pharmacologiques
|January 1, 1996
Summary
This study examines 10 patients with autoimmune hepatitis type 2b and Hepatitis C virus (HCV) infection. Treatment with corticosteroids or interferon showed varied outcomes, highlighting the need for tailored therapeutic strategies.
Area of Science:
- Hepatology
- Immunology
- Virology
Background:
- Autoimmune hepatitis (AIH) can coexist with viral infections.
- Hepatitis C virus (HCV) infection is a global health concern.
- Type 2b autoimmune hepatitis is characterized by anti-LKM1 antibodies.
Purpose of the Study:
- To investigate the clinical presentation and outcomes of patients with coexisting type 2b autoimmune hepatitis and HCV infection.
- To evaluate the efficacy and adverse effects of different treatment modalities in this patient cohort.
Main Methods:
- Case series of 10 Italian patients with type 2b AIH and HCV.
- Assessment of autoantibodies (anti-LKM1, ANA, SMA, pANCA, anti-GOR), IgG levels, and liver histology.
- Detection of HCV antibodies and RNA.
- Analysis of treatment responses to corticosteroids and interferon.
Main Results:
- All patients tested positive for HCV antibodies, with 9 having detectable HCV RNA.
- Elevated IgG levels and histological evidence of chronic liver disease were common.
- Corticosteroid treatment led to remission but relapse upon withdrawal.
- Interferon therapy was effective in some but induced autoimmune thyroiditis in two patients.
Conclusions:
- The interplay between HCV infection and autoimmune hepatitis requires careful consideration for treatment.
- Tailored treatment strategies are crucial, balancing the management of viral hepatitis and autoimmune liver disease.
- Further research is needed to determine if HCV triggers autoimmunity or if these conditions occur concurrently.