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[Urologic manifestations in Wolfram's syndrome]
J Monllor Gisbert1, F Taño Pino, P Rodríguez Arteaga
1Servicio de Urología, Complejo Hospitalario Ntra, Sra. de Candelaria, Santa Cruz de Tenerife.
Actas Urologicas Espanolas
|May 1, 1996
Summary
Wolfram syndrome, a rare genetic disorder, can present with significant urological issues like ureterohydronephrosis and neurogenic bladder. These conditions improved with antibiotics and intermittent catheterism.
Area of Science:
- Genetics
- Urology
- Endocrinology
Background:
- Wolfram syndrome is a rare genetic disorder characterized by the association of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.
- Urological complications are not commonly highlighted in Wolfram syndrome literature.
Observation:
- This paper presents two case reports of patients with Wolfram syndrome experiencing significant urological symptoms.
- The observed urological conditions included ureterohydronephrosis and neurogenic bladder.
Findings:
- Radiological and urodynamic assessments were performed to evaluate the urological conditions.
- The study comments on the probable origins and natural evolution of these urological manifestations.
Implications:
- The urological symptoms in these Wolfram syndrome cases showed a favorable response to treatment.
- Treatment involved antibiotics and intermittent vesical catheterism, suggesting potential management strategies for urological complications in Wolfram syndrome.