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4-(1-Naphthylamino)-piperidines as inhibitors of lipid peroxidation
G Domány1, G Barta-Szalai, A Gere
1Chemical Works of Gedeon Richter Ltd., Budapes, Hungary.
Arzneimittel-Forschung
|June 1, 1996
Abstract:
Some analogues of (+/-)-N-methyl-N-¿1-[3-(4-fluorophenoxy)-2-hydroxy-propyl]-piperidin+ ++-4-yl¿ benzothiazol-2-amine (sabeluzole, CAS 104383-17-7), a series of 4-(l-naphthylamino)-piperidines (1a-1h), are potent inhibitors of both NADPH- and Fe(2+)-dependent lipid peroxidation (IC50 < 10 mumol/1). It was demonstrated that the naphthylaminopiperidine moiety is responsible for this effect due to its antioxidant property, verified by cyclic voltammetric studies.