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Anthelmintic activity of 6,7-diaryl-pteridines
C Ochoa1, J Rodríguez, M L López García
1Instituto de Quimica Medico, Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
Arzneimittel-Forschung
|June 1, 1996
Abstract:
In a search for new anthelmintic compounds, some 6,7-diaryl-pteridines were synthesized from the corresponding diaminopyrimidines and aromatic aldehydes. Their anthelmintic activity was tested in vitro against Caenorhabditis elegans and Heligmosomoides polygyrus and in vivo against Trichinella spiralis. Structure-activity relationships are discussed.