Related Experiment Videos
Quinazolinone derivatives: synthesis and binding evaluation on cholecystokinin receptors
A Varnavas1, L Lassiani, E Luxich
1Dipartimento di Scienze Farmaceutiche, Università di Trieste, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|May 1, 1996
Abstract:
A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amino-4(H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands.