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Quinolone derivatives: synthesis and binding evaluation on cholecystokinin receptors
A Varnavas1, L Lassiani, E Luxich
1Dipartimento di Scienze Farmaceutiche, Università di Trieste, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|May 1, 1996
Abstract:
A series of 1,2-dihydro-4-phenylquinolin-2-one-3-carboxylic acid and of 3-amino-4-phenylcarbostyril derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-A rather than CCK-B receptor and the results have been discussed on the basis of a molecular modelling study.