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[Biomimetic oxidation of clemastine hydrogen fumarate]
L Fröhlich1, B Pietzyk, K Smolinka
1Institut für Pharmazie, Humboldt-Universität zu Berlin, Germany.
Die Pharmazie
|June 1, 1996
Abstract:
The reaction of clemastine fumarate (1) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluoro-water. The reaction of 1 in aqueous solution with manganese(III)-5,10,15,20-tetrakis (pentafluorophenyl)-beta-tetrasulfonatoporphyrin chloride (MnTPFPS4PCl) as catalyst additional generates products of aromatic hydroxylation. Products were identified by TLC, UV, and MS. Thereby we found a close conformity with rat metabolism.