Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus
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Updated: Nov 4, 2026
06:56
Development and Application of Rapamycin-regulated Tyrosine Phosphatases
Published on: September 6, 2024
1Fermentation Microbiology Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA.
Folia Microbiologica
|January 1, 1995
Abstract:
A chemically defined medium was developed which satisfies the nutritional needs of the Streptomyces hygroscopicus strain producing the immunosuppressant rapamycin. More than a doubling of rapamycin biosynthesis was observed on addition of 57 mmol/L of exogenous shikimate. The previously observed inhibition of the synthesis by phenylalanine was not reversed by shikimate.
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