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Intravascular coagulation and fibrinolysis

R L Palmer

    Postgraduate Medicine
    |July 1, 1977
    PubMed
    Summary

    Intravascular coagulation, a serious condition where plasma converts to serum, can cause bleeding or clotting. Key diagnostics include platelet count and fibrinogen levels to guide treatment.

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    Area of Science:

    • Hematology
    • Pathophysiology
    • Clinical Medicine

    Background:

    • Intravascular coagulation is a complication of numerous conditions.
    • It involves the conversion of plasma to serum within the circulation.
    • Manifestations range from hemorrhagic to thrombotic events.

    Purpose of the Study:

    • To outline the diagnostic approach to intravascular coagulation.
    • To discuss management strategies for this complex condition.

    Main Methods:

    • Review of clinical and laboratory findings in intravascular coagulation.
    • Emphasis on diagnostic tests such as platelet count and fibrinogen determination.
    • Consideration of fibrin degradation product testing when indicated.

    Main Results:

    • Platelet count and fibrinogen levels are crucial diagnostic indicators.
    • Abnormalities necessitate further testing for fibrin degradation products.
    • Management prioritizes addressing the underlying cause.

    Conclusions:

    • Heparin therapy is recommended for concurrent clotting and severe fibrinolysis.
    • The utility of clotting factor replacement remains under discussion.
    • Prompt diagnosis and management are essential for patient outcomes.

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