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Evaluating renal function: current status of clinical tests

L R Crowe, F E Hatch

    Postgraduate Medicine
    |July 1, 1977
    PubMed
    Summary
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    Assessing kidney function involves evaluating glomerular function, tubular function, and renal plasma flow. While creatinine clearance measures glomerular function and urine concentration assesses tubular function, accurate tests for renal plasma flow are currently lacking.

    Area of Science:

    • Nephrology
    • Renal Physiology

    Background:

    • Renal function tests are crucial for diagnosing and managing kidney diseases.
    • Current methods primarily focus on glomerular and tubular functions, with less emphasis on renal plasma flow.

    Purpose of the Study:

    • To review current methods for assessing renal function, including glomerular filtration, tubular handling, and renal plasma flow.
    • To highlight the limitations of existing tests, particularly for renal plasma flow.

    Main Methods:

    • Review of established clinical practices for renal function assessment.
    • Analysis of diagnostic criteria for glomerular and tubular function.
    • Evaluation of available methods for measuring renal plasma flow.

    Main Results:

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    • Endogenous creatinine clearance is the recommended initial test for glomerular function.
    • Urine concentrating ability is the most reliable clinical indicator of tubular function.
    • No accurate and readily available test currently exists for measuring renal plasma flow.

    Conclusions:

    • Accurate assessment of renal function requires evaluating multiple parameters.
    • Further research is needed to develop reliable methods for measuring renal plasma flow.
    • Clinical practice relies on established tests for glomerular and tubular function due to current limitations.