[The effect of global cerebral ischemia on erythrocyte deformability and cerebral microcirculation in dogs]

The state of cerebral ischemia and the following recirculation affect also the blood rheology. The erythrocyte microrheology was studied less than the blood plasma changes. The presented paper is focused on the erythrocyte microrheology changes after global brain ischemia. Both mild and serious global ischemia were induced by the exclusion of cerebral blood circulation for seven min. Thereafter followed the period of recirculation. The changes of erythrocyte microrheology were studied using the method of colloid-osmotic hemolysis. After 180 minutes of recirculation, a significant increase of colloid-osmotic hemolysis was observed. After this until the 240th a significant decrease of colloid-osmotic hemolysis followed. In the group in which mild cerebral ischemia was induced the above mentioned changes were only slightly presented. Important is the fact that the changes in erythrocyte microrheology after serious brain ischemia are in correlation with the changes in cerebral microcirculation. After serious brain ischemia the trombotisation as well as the blood stasis occurred (no-reflow phenomenon).