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Thrombophilia in patients with hypercholesterolemia
P Chan1, B Tomlinsoin, C W Tsai
1Department of Medicine, Taipei Municipal Chung-Hsiao Hospital, Taiwan.
Metabolism: Clinical and Experimental
|August 1, 1996
Summary
Hypercholesterolemia is linked to blood clotting abnormalities, specifically elevated fibrinogen and factor VIIc. These hemostatic changes may contribute to increased cardiovascular risk in affected individuals.
Area of Science:
- Cardiovascular Medicine
- Hemostasis and Thrombosis
- Metabolic Disorders
Background:
- Hypercholesterolemia is a known risk factor for cardiovascular disease.
- The relationship between high cholesterol and the coagulation and fibrinolytic systems requires further investigation.
Purpose of the Study:
- To explore the interrelationship between hypercholesterolemia and hemostatic factors.
- To identify specific coagulation and fibrinolytic parameters affected by high cholesterol levels.
Main Methods:
- Longitudinal prospective study in Taiwan involving hemostatic measurements.
- Measured parameters included prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, factor VIIc, factor VIIIc, antithrombin III, and plasminogen.
- Statistical analysis using Pearson correlation and multiple regression.
Main Results:
- Hypercholesterolemic subjects (> 6.2 mmol/L) showed elevated fibrinogen, factor VIIc, diastolic blood pressure, plasma glucose, and triglycerides.
- Reduced PT and APTT were observed in hypercholesterolemic individuals.
- Factor VIIc was the most significant parameter correlated with cholesterol levels; anticoagulant factors (antithrombin III, plasminogen) were also elevated.
Conclusions:
- Hemostatic abnormalities, a thrombophilic state, are present in hypercholesterolemia.
- These findings provide insights into the higher cardiovascular mortality associated with hypercholesterolemia.