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Related Experiment Videos

Fatal digoxin overdose

D P Nicholls

    Postgraduate Medical Journal
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Cardiac glycoside overdose is common but rarely fatal. This case details cardiac arrest with a record high serum digoxin level of 50.4 µg/L after oral administration, highlighting extreme toxicity potential.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Cardiology

    Background:

    • Cardiac glycosides, like digoxin, are widely used for heart conditions.
    • Overdosage is known, but typically not lethal.
    • Therapeutic drug monitoring is crucial for managing toxicity.

    Observation:

    • A patient presented with cardiac arrest in asystole.
    • The patient had ingested digoxin orally.
    • An exceptionally high serum digoxin concentration was measured.

    Findings:

    • The serum digoxin level was 50.4 µg/L, the highest reported post-oral administration.
    • This extreme level was associated with fatal cardiac arrest.
    • The case underscores the potential for severe toxicity even with oral intake.

    Implications:

    • This case highlights the critical need for vigilant digoxin level monitoring.
    • It emphasizes the potential for life-threatening outcomes in severe cardiac glycoside overdose.
    • Further research into managing extreme digoxin toxicity may be warranted.