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Updated: Jan 30, 2026

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
Published on: May 30, 2025
Implications of cellular and molecular biology advances in periodontal regeneration
1Department of Oral Biology and Periodontology, Boston University, Massachusetts.
Background:
The mechanisms by which new periodontium is established on root surfaces previously exposed to periodontal disease has been an area of active research interest for the past decade.
Methods:
Recently, histological examination of periodontal regeneration has revealed a complex process orchestrated by temporo-spatial specific cell-matrix interactions.
Results:
Advances in cell and molecular biology techniques have provided invaluable tools to begin investigating the cascade of events occurring periodontal regeneration.
Conclusion:
This report summarizes current understanding of the cellular and molecular aspects of periodontal regeneration and determines the clinical relevance of these findings.
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