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Lipid peroxidation in hepatocellular carcinoma
H Iwagaki1, K Hamazaki, N Matsubara
1First Department of Surgery, Okayama University Medical School, Japan.
Acta Medica Okayama
|December 1, 1995
Abstract:
In this study, we measured free radicals and thiobarbituric acid-reactive substances (TBARS) in hepatocellular carcinoma and in non-cancerous liver parenchyma. There was a higher concentration of free radicals in malignant tissue than in non-cancerous tissue. In contrast, the level of TBARS was significantly (P < 0.01) lower than non-cancerous liver parenchyma. These paradoxical results suggested that antioxidative enzyme activity and/or inhibition of lipid peroxidation were higher in hepatocellular carcinoma.