Related Experiment Video

Updated: Sep 7, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 3, 2007

Acute disseminated encephalomyelitis: MR and CT features

I Mader1, K W Stock, T Ettlin

  • 1Department of Diagnostic Radiology, University Hospital/Kantonsspital, Basel, Switzerland.

AJNR. American Journal of Neuroradiology
|January 1, 1996
PubMed

Insights

Acute disseminated encephalomyelitis (ADEM) presents with varied radiological features, including ring-enhancing lesions and solid disseminated lesions. Histology reveals distinct patterns in this immune-mediated central nervous system disease.

Area of Science:

  • Neuroimmunology
  • Neuroradiology
  • Neuropathology

Background:

  • Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory demyelinating disease affecting the central nervous system.
  • Understanding ADEM's diverse radiological manifestations is crucial for accurate diagnosis and management.

Observation:

  • This study details three cases of ADEM with distinct histological findings.
  • Radiological imaging revealed varied appearances, including ring-enhancing lesions and solid disseminated lesions.

Findings:

  • Ring-shaped enhancing lesions were predominantly observed in the supratentorial white matter.
  • Histological examination correlated with these different radiological patterns, highlighting ADEM's heterogeneity.

Implications:

  • These findings emphasize the importance of integrating radiological and pathological data for ADEM diagnosis.
  • Recognizing diverse ADEM presentations can improve patient outcomes and guide therapeutic strategies.

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