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Related Concept Videos

X-ray Crystallography02:18

X-ray Crystallography

21.6K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
21.6K
X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

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X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
3.8K
Determination of Crystal Structures01:29

Determination of Crystal Structures

135
In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
135

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Related Experiment Video

Updated: Apr 30, 2026

Protein Crystallization for X-ray Crystallography
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Protein Crystallization for X-ray Crystallography

Published on: January 16, 2011

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Protein crystallography in Australia

M W Parker1

  • 1Ian Potter Foundation Protein Crystallography Laboratory, St. Vincent's Institute of Medical Research, Melbourne, Vic.

Australian and New Zealand Journal of Medicine
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Protein crystallography reveals 3D protein structures, aiding drug design and understanding biological processes. This field is rapidly expanding globally and in Australia, with applications in pharmaceutical development and cancer research.

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Microcrystallography of Protein Crystals and In Cellulo Diffraction
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Microcrystallography of Protein Crystals and In Cellulo Diffraction

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Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron
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Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron

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Related Experiment Videos

Last Updated: Apr 30, 2026

Protein Crystallization for X-ray Crystallography
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Microcrystallography of Protein Crystals and In Cellulo Diffraction
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Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron
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Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron

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Area of Science:

  • Structural biology
  • Biochemistry
  • Drug discovery

Background:

  • Protein crystallography provides near-atomic resolution 3D protein structures.
  • It offers insights into biological processes and drives pharmaceutical innovation.
  • The field is experiencing significant global expansion, including in Australia.

Purpose of the Study:

  • To highlight the growth and importance of protein crystallography.
  • To detail the research focus of the Protein Crystallography Unit at St Vincent's Institute of Medical Research.
  • To emphasize the role of structural biology in drug development, particularly for anti-cancer agents.

Main Methods:

  • Protein crystallography techniques for structural elucidation.
  • Structure-based inhibitor studies.
  • Focus on membrane proteins and specific protein families.

Main Results:

  • Demonstrated the expansion of protein crystallography research in Australia.
  • Advanced the structural understanding of membrane proteins.
  • Identified potential structure-based inhibitors for anti-cancer drug development.

Conclusions:

  • Protein crystallography is a crucial and expanding field with significant implications for medicine.
  • Structural insights are vital for designing novel therapeutics, including anti-cancer drugs.
  • The Protein Crystallography Unit contributes to this field through its research on membrane proteins and inhibitor studies.