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Related Experiment Videos

Differences between Papanicolaou smears with correct and incorrect diagnoses

H Mitchell1, G Medley

  • 1Victorian Cytology Service, Carlton South, Australia.

Cytopathology : Official Journal of the British Society for Clinical Cytology
|December 1, 1995
PubMed
Summary

Fewer than 50 abnormal cells on Papanicolaou smears significantly increased the risk of false negative cervical cancer reports. These findings suggest rapid rescreening of negative slides may not effectively reduce false negatives.

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Area of Science:

  • Cervical cancer screening
  • Cytopathology
  • Gynecologic oncology

Background:

  • Papanicolaou (Pap) smears are crucial for detecting cervical dysplasia and cancer.
  • False negative results in Pap smear interpretation can lead to delayed diagnosis and treatment.
  • Understanding the characteristics of false negative slides is essential for improving screening accuracy.

Purpose of the Study:

  • To compare the cytomorphological features of false negative and true positive Papanicolaou smears in women with cervical intraepithelial neoplasia grade III (CINIII).
  • To identify factors associated with false negative Pap smear reports in CINIII cases.

Main Methods:

  • A case-control study design was employed.
  • Papanicolaou smears from women diagnosed with CINIII were analyzed.

Related Experiment Videos

  • Slides with false negative reports were compared to slides with true positive reports.

    • Main Results:

    • The number of abnormal cells was the most significant factor differentiating false negative from true positive slides.
    • Slides with fewer than 50 abnormal cells had a 23.7 times greater odds of a false negative report compared to slides with 200 or more abnormal cells.
    • False negative slides were characterized by sparse abnormal cells, often appearing as single cells, small in size, and with finely granular, normochromatic nuclei, not represented throughout the slide.

    Conclusions:

    • Intrinsic cytomorphological differences exist between true positive and false negative Pap smear slides for CINIII.
    • The characteristics of abnormal cells in false negative slides suggest that rapid rescreening of negative cases may not be an effective strategy for reducing the false negative rate.