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Related Experiment Videos

Drug variables in thrombolytic therapy

M F Meyerovitz1

  • 1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Journal of Vascular and Interventional Radiology : JVIR
|November 1, 1995
PubMed
Summary

Fibrinolytic therapy using agents like streptokinase and urokinase effectively treats arterial occlusions. This review examines dosing, results, and new agents for peripheral arterial and bypass graft occlusions.

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Area of Science:

  • Vascular Medicine
  • Interventional Cardiology

Background:

  • Fibrinolytic therapy is a key treatment for peripheral arterial and bypass graft occlusions.
  • Agents like streptokinase, urokinase, and tissue plasminogen activator are used for intraarterial infusion.

Purpose of the Study:

  • To review dosing variables and clinical outcomes of thrombolytic agents in peripheral arterial and bypass graft occlusions.
  • To discuss emerging thrombolytic agents and the impact of adjunctive therapies.

Main Methods:

  • Literature review of studies on fibrinolytic therapy for peripheral arterial and bypass graft occlusions.
  • Analysis of protocols, dosing, and clinical results for various thrombolytic agents.

Main Results:

  • Variable protocols and results reported for streptokinase, urokinase, and tissue plasminogen activator.
  • Focus on optimizing treatment through dosing and understanding new agents.

Conclusions:

  • Fibrinolytic therapy is an established treatment for arterial occlusions.
  • Further research into new agents and combination therapies may improve outcomes.

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