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Related Experiment Videos

NMR functional imaging using a tailored RF gradient echo sequence: a true susceptibility measurement technique

Z H Cho1, Y M Ro, S T Park

  • 1Department of Radiological Sciences, University of California, Irvine 92717, USA.

Magnetic Resonance in Medicine
|January 1, 1996
PubMed
Summary

Tailored radio frequency gradient echo (TRFGE) functional imaging enhances signals from local field gradients, improving functional MRI data analysis. This technique is ideal for precise susceptibility effect measurements in human volunteers.

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Area of Science:

  • Magnetic Resonance Imaging
  • Functional Neuroimaging

Background:

  • Tailored radio frequency gradient echo (TRFGE) is a technique previously used in venography.
  • Functional MRI (fMRI) analysis can be complicated by in-flow effects from arterial blood.

Purpose of the Study:

  • To apply the TRFGE technique to functional imaging.
  • To evaluate the TRFGE technique's sensitivity to susceptibility effects and insensitivity to in-flow effects.

Main Methods:

  • Experiments were conducted on human volunteers using a 2.0T MRI system.
  • Various imaging parameters (flip angle, repetition time, echo time) were systematically examined.
  • TRFGE functional imaging results were compared to conventional gradient echo fMRI.

Main Results:

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  • TRFGE enhances signals from regions with local field gradients caused by susceptibility effects.
  • The TRFGE technique demonstrates insensitivity to arterial blood in-flow effects.
  • Functional MRI data analysis is simplified by minimizing in-flow artifacts.

Conclusions:

  • TRFGE is well-suited for functional MR imaging requiring accurate susceptibility effect measurements.
  • The TRFGE sequence offers advantages for functional neuroimaging by focusing on true susceptibility effects.