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Related Experiment Videos

Perfusion imaging with compensation for asymmetric magnetization transfer effects

J Pekar1, P Jezzard, D A Roberts

  • 1Laboratory of Diagnostic Radiology Research, OIR, National Institutes of Health, Bethesda, MD 20892, USA.

Magnetic Resonance in Medicine
|January 1, 1996
PubMed
Summary

Off-resonance radio-frequency irradiation affects MR signals in cat brains asymmetrically. This finding is crucial for accurate arterial spin tagging (AST) in brain imaging, especially for quantitative cerebral blood flow measurements.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Neuroimaging
  • Biophysics

Background:

  • Off-resonance radio-frequency irradiation influences MR signal intensity.
  • Magnetization transfer (MT) effects are inherent in certain MRI techniques.
  • Arterial spin tagging (AST) is a method for measuring blood flow.

Purpose of the Study:

  • To investigate the asymmetric effects of off-resonance radio-frequency irradiation on cat brain MR signals.
  • To address the challenge of magnetization transfer asymmetry in AST.
  • To present methods for correcting or circumventing MT spectral shifts in AST.

Main Methods:

  • Analysis of MR signal intensity changes due to off-resonance irradiation.
  • Characterization of magnetization transfer spectrum shifts.

Related Experiment Videos

  • Development and application of two novel approaches to compensate for MT effects in AST.
  • Acquisition of cat brain perfusion images using flow-induced adiabatic inversion of arterial water protons.

    • Main Results:

    • Observed asymmetric effects of radio-frequency irradiation on water proton MR signals in the cat brain.
    • Identified an upfield shift in the magnetization transfer spectrum (approx. 1.5 ppm).
    • Demonstrated successful compensation for MT effects using presented approaches.
    • Acquired perfusion images of the cat brain using a modified AST technique.

    Conclusions:

    • The asymmetry in MT effects must be accounted for in AST to ensure accurate quantitative cerebral blood flow (CBF) measurements.
    • The presented methods offer solutions for correcting or circumventing MT spectral shifts in AST.
    • Further considerations for obtaining precise CBF values using AST are discussed.