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Ovarian Sertoli-Leydig cell tumor with retiform pattern

K Moyles1, Y F Chan, J Hamill

  • 1Histopathology Laboratory and Paediatric Surgery, Auckland, New Zealand.

Pathology
|October 1, 1995
PubMed
Summary

Sertoli-Leydig cell tumors (SLCT) are rare ovarian neoplasms. This report details a unique case of a retiform pattern SLCT in a 7-year-old girl, highlighting diagnostic challenges in pediatric oncology.

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Area of Science:

  • Gynecologic Oncology
  • Pediatric Pathology
  • Reproductive Endocrinology

Background:

  • Sertoli-Leydig cell tumors (SLCT) are rare sex cord-stromal ovarian neoplasms with testicular differentiation.
  • While accounting for <0.2% of all ovarian neoplasms, SLCT represent 4% of ovarian tumors in females under 20.
  • These tumors exhibit significant morphological variability, classified histologically into five categories.

Observation:

  • This report presents a rare case of an ovarian Sertoli-Leydig cell tumor (SLCT) with a retiform pattern.
  • The patient was a 7-year-old girl, making this a pediatric presentation of a typically adult-onset tumor.
  • The retiform pattern is one of the less common histological subtypes of SLCT.

Findings:

  • The case highlights the diverse histological presentations of SLCT, including the retiform pattern.

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  • Diagnosis in young children can be challenging due to the rarity and varied morphology of these tumors.
  • The specific histological subtype (retiform) influences tumor behavior and management.

    • Implications:

    • Early and accurate diagnosis of SLCT in pediatric patients is crucial for appropriate management.
    • Understanding the histological variants, such as the retiform pattern, aids in predicting tumor prognosis.
    • This case contributes to the literature on rare pediatric ovarian tumors, informing clinical practice and research.