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Generalized chorea in an infant with semilobar holoprosencephaly
E D Louis1, T Lynch, A L Cargan
1Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Pediatric Neurology
|November 1, 1995
Abstract:
We report chorea in an infant with holoprosencephaly. Congenital structural brain disease has not been a reported cause of chorea. Cranial magnetic resonance imaging revealed small, fused frontal lobes with hypoplastic caudates. Our patient responded to symptomatic treatment with dopamine-depleting agents. It is likely that the mechanism for the chorea was a dysfunction of the striatum. The differential diagnosis of childhood chorea should include holoprosencephaly.